Ten times the effect of general florfenicol.
The maximum blood drug concentration can be reached within 30 minutes.
Oral administration can replace intramuscular injection.
[Main ingredients] florfenicol
[Character] This product is white or almost white powder.
[Function and use] Amide alcohol antibiotics. It is used to treat bacterial infection caused by chicken sensitive bacteria.
[Usage and dosage of Bonsenberg]
Prevention: 100g of this product is mixed with 500kg of water.
Treatment: 100g of this product mixed with water 200-250kg.
Preferred drug for reducing the use of antibiotics
It can reduce the dosage by 5-10 times ---- BonsenForge
Advantages of Shanghai Bonsen patent florfenicol
Through amorphous technology, florfenicol can be rapidly absorbed, reach the bactericidal blood concentration within 15 minutes after application, and reach the peak of blood concentration within 30 minutes, so that a small amount of use and a large amount of absorption can be achieved, which has the same effect as intramuscular injection, and overcome the shortcomings of different animal absorption rates, so that the oral absorption rate of livestock and poultry can reach more than 96%. Shanghai Bonsen's patented florfenicol products: Bonsen Fuch-5% florfenicol soluble powder, and Bonbone-2% florfenicol premix, which can make florfenicol rapidly absorbed in the body through amorphous technology.
Pharmacological action
Pharmacodynamics florfenicol belongs to amide alcohol broad-spectrum antibiotic, belongs to bacteriostatic agent, and plays a role by combining with ribosomal 50S subunit to inhibit bacterial protein synthesis. It has strong antibacterial activity against a variety of gram-positive bacteria and gram-negative bacteria. Pasteurella haemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae are highly sensitive to florfenicol. In vitro, the antibacterial activity of florfenicol against many microorganisms is similar to or stronger than that of thiamphenicol. Some bacteria that are resistant to amide alcohols due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be sensitive to florfenicol. It is mainly used for bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, such as respiratory diseases of cattle and pigs caused by Pasteurella haemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae. Typhoid and paratyphoid fever caused by Salmonella, chicken cholera, chicken pullorum, colibacillosis, etc; Bacterial septicemia, enteritis, red skin disease, etc. of fish caused by Pasteurella, Vibrio, Staphylococcus aureus, Hydromonas hydrophila, enteritis bacteria, etc.
Pharmacokinetics Flufenicol is absorbed rapidly after oral administration, and the therapeutic concentration can be reached in the blood after about 1 hour, and the peak blood concentration can be reached in hours. The bioavailability is above. Flufenicol is widely distributed in animals and can penetrate the blood-brain barrier. It is mainly excreted from urine in its original form, and a small amount is excreted with stool.
Specifications: 5%
packing: 100g/bag
Storage: Keep it in a dry place.
Executive standards: Veterinary Pharmacopoeia of the People's Republic of China, Volume 1, 2015
Approval No: Veterinary Medicine No. 163486272
Different absorption rates of oral florfenicol
Generally, flufenicol is almost completely absorbed by pigs after oral administration. The absorption rate of fish is more than 96%. The absorption rate of broilers is relatively low at 55.3%, and that of cattle is about 54%. However, when injected intramuscularly, the absorption rate is more than 96%. How to quickly improve the low absorption rate of oral administration to complete absorption, and how to achieve high absorption and utilization rate with a small amount of drugs, just like the effect of intramuscular injection. Use amorphous technology to improve the rapid absorption of florfenicol.
Comparison of dissolution results in vitro between Bonsenberg and ordinary florfenicol
1. Bonsenberg uses amorphous (amorphous) technology to keep florfenicol in a high-energy state, improve the solubility of florfenicol in water, and ensure that florfenicol can be rapidly dissolved, thus improving the intestinal absorption rate.
2. After oral administration of Bonsenberg, it can be rapidly absorbed in livestock and poultry, and the peak concentration of blood drug can be reached within 30 minutes
Blood concentration and time curve of Bonsenberg and other florfenicol after intragastric administration in chicken (50mg/kg body weight, oral)
(Bonsenberg can reach the peak of effective bactericidal blood concentration in 0.5 hour)
Bonsenflufenicol was prepared into 0.5mg/ml solution, and the chicken was gavaged with 50mg/kg body weight to determine the blood drug concentration at different times.
Comparison preparation: foreign similar products are positive control, and florfenicol raw materials are negative control.
3. The after-effect of the drug can reach more than 12 hours, and the sub-inhibitory concentration after the drug is low, which can be maintained at 20 hours (that is, the bacteriostatic and bactericidal effect can be maintained for 12 hours after the drug is used)
After the absorption promotion optimization treatment of Bonsenberg (amorphous patented technology), it can produce larger Cmax than the solution, and can produce the longest (post-antibiotic effect) PAE.
Bonsenberg said that the same dosage produced greater absorption efficiency, which is significant for reducing drug residues in animal excreta and reducing bacterial resistance.
4. No drug residue, no drug resistance, rapid absorption, complete, small dosage and excellent effect.
The effect is good, which is 10 times that of ordinary florfenicol (1g of this product is equivalent to 10g of the national standard florfenicol).
Problems of common florfenicol
1. The solubility of florfenicol in water is low (1.2 mg/ml, preferably more than 10 mg/ml), and the dissolution of powder medicine is slow, resulting in slow and incomplete absorption.
2. Ordinary florfenicol is only mixed with sugar or other excipients. The absorption rate in vivo is generally about 1-2h, and the dissolution absorption rate is slow. Therefore, it is necessary to increase the dosage to improve the blood concentration.
3. A large amount of drug use can easily cause large drug residue and toxicity in livestock and poultry, cause damage to liver, spleen, kidney and other organs, and cause damage to hematopoietic stem cells, resulting in slow growth of livestock and poultry, embryo malformation, stunting, anemia, hair blasting and other effects on high yield and efficiency.
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